Overview of Cardiovascular Endoscopy Imaging of Atherosclerosis using Photoacoustic Techniques with Pulsed-Laser and Continuous-Wave-Laser Optical Excitation
Abstract
Intravascular photoacoustics (IV-PA) is an emerging atherosclerosis imaging modality that provides molecularly-specific optical information of arterial walls with ultrasonic depth penetration and resolution. As lipid composition of atherosclerotic plaques is considered to be one of the primary indicators for plaque vulnerability, many IV-PA applications are calibrated so as to target plaque necrotic cores. Based on the mode of optical excitation and the corresponding signal processing technique, IV-PA is categorized into two different modalities. The pulsed-laser-based IV-PA has been the universal IV-PA imaging mode with its high peak power and straightforward time-domain signal processing technique. As an alternative, the low power continuous-wave (CW)-laser-based IV-PA has been under intense development with its radar- (or sonar-) like frequency-domain (FD-PA) signal processing methodologies. In this keynote lecture, the two state-of-the-art types of IV-PA are reviewed in terms of their physics and imaging capabilities, with emphasis on CW-based endoscopic IV-PA imaging of animal and human arteries currently under development at the Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT). These results are significant for further near-future IV-PA endoscopy image resolution improvements toward the very early diagnosis of coronary disease.
Short Biography
Andreas Mandelis, is a Full Professor of Mechanical and Industrial Engineering Electrical and Computer Engineering and the Institute of Biomaterials and Biomedical Engineering, University of Toronto. He is the Canada Research Chair in Diffusion-Wave and Photoacoustic Sciences and Technologies. He is the Director of the Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT) and of the new Institute for Advanced Non-Destructive and Non-Invasive Diagnostic Technologies (IANDIT) at the University of Toronto. He is the author and co-author of 430+ scientific papers in refereed journals and 190+ scientific and technical proceedings papers. He is an Associate Editor of the AIP Journals Review of Scientific Instruments, Journal of Applied Physics and a member of the editorial board of the SPIE Journal of Biomedical Optics. He is also a Contributing Editor of the AIP flagship magazine Physics Today. He has several inventions, 40 patents and patents pending in the areas of photothermal tomographic imaging, signal processing and measurement, hydrogen sensors, dental laser diagnostics (biothermophotonics), several semiconductor non-destructive diagnostic technologies and laser biophotoacoustic and biothermophotonic tissue imaging.